A single dose of kudzu extract reduces alcohol consumption in a binge drinking paradigm

Lukas recruited 14 men and women in their 20s to spend four 90-minute sessions consuming beer and watching TV. Researchers selected people who said they regularly consumed three to four drinks per day. Findings show that subjects who took kudzu drank an average of 1.8 beers per session, compared with the 3.5 beers consumed by those who took a placebo. There’s some evidence that kudzu root supplements may cause liver injury, but more research needs to be done on this topic. Animal studies suggest that kudzu root could have heart-protective benefits.

Is kudzu good for alcoholism?

Readings of historical Chinese texts (Li, 1590–1596; Sun, circa 600 AD) reveal that extracts of the kudzu root have been used to treat alcoholism and drunkenness since at least 600 AD.

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Analyzing Ingredients in Dietary Supplements and Their Metabolites

Robinin in kudzu leaf has also been reported.(Saĭiad 1979b) Other constituents evaluated include daidzin, daidzein, genistein, genestin, tectoridin, kakkalide, formononetin, biochanin A, and plant sterols. In addition, morphological and anatomical kudzu extract for alcoholism identification studies of kudzu have been performed. Penetar DM, Teter CJ, Ma Z, Tracy M, Lee DY-W, Lukas SE. Pharmacokinetic profile of the isoflavone puerarin after acute and repeated administration of a novel kudzu extract to human volunteers.

How much kudzu is needed for alcoholism?

Kudzu (2 mg) will be administered as a pretreatment 2 ½ hours before a drinking session to see if it will significantly reduce the number of drinks consumed during a single 1 ½ hours drinking session. Other Names: Kudzu root extract (NPI-031) Puerariae lobata.

Potential health perks of taking kudzu root include decreasing alcohol intake, easing menopause symptoms, and regulating blood sugar levels. This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition.

Cardiovascular effects

Heated, aqueous extraction of soybeans to make soy milk and tofu, removes the malonyl group to make daidzin . Fermentation can also lead to hydrolysis of the glucosyl group . A standardized kudzu extract (NPI-031) reduces alcohol consumption in nontreatment-seeking male heavy drinkers. Another study found that kudzu may really “affect alcohol consumption patterns.” In this same study, people who took an isoflavone extract from the kudzu plant before drinking took longer to reach for the liquor cabinet.

kudzu extract for alcoholism

Kudzu root is rich in antioxidants, compounds that protect cells from oxidative stress that can lead to disease. The isoflavone puerarin is the most abundant antioxidant compound in the kudzu vine . Read online reviews of that particular kudzu https://ecosoberhouse.com/ root supplement to find out more about other folks’ experiences. Kudzu root is an edible part of a climbing vine that’s native to many Asian countries. It’s been used for health purposes in Traditional Chinese Medicine for a really long time.

Kudzu root benefits

Most of the puerarin eliminated is unchanged, but a small amount is metabolized in the liver by cytochrome p450 and through conjugation to daidzein. The authors speculate that a delay in gastric emptying due to the increased bulk of the 4 capsules taken in the acute 2 g dose study may explain the unusual increase in Tmax, compared with the acute 1 g dose. The results also indicate a one-compartment pharmacokinetic profile for puerarin.

However, all of these studies enrolled small numbers of patients, and systematic reviews have determined that the evidence of benefit for any condition is unclear. The researchers observed 12 men and women in a double-blind placebo-controlled study. The participants were either treated with kudzu or a placebo for nine days, and then received a medium or high alcohol challenge to determine how prominently they presented alcohol-related symptoms. Animal and in vitro studies have demonstrated anti-inflammatory effects of kudzu leaf and root extracts, as well as its active constituents puerarin and robinin. In mouse peritoneal macrophages, kudzu leaf extract was a more potent inhibitor of the inflammatory proteins inducible nitric oxide synthase , COX-2, TNF-alpha, and IL-6. Robinin, found predominantly in kudzu leaves and not the roots, was found to inhibit interferon-gamma and iNOS production but not TNF-alpha, COX-2, or IL-6.

What is Kudzu Root?

Those in attendance took a liking to the plant for its beauty and long vines. Many people began to grow it in their backyards for ornamental display. Today, the kudzu vine grows across Southeast Asia, in the Pacific Islands and in North America.

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